Proceedings on Automation in Medical Engineering
Vol. 2 No. 1 (2023): Proc AUTOMED

Automation in lung support and ventilation, ID 723

A simple mathematical lung model of Chronic Obstructive Pulmonary Disease (COPD)

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Carlotta Hennigs (Universität zu Lübeck, Institut of Electrical Engineering in Medicine), Franziska Schollemann (Universität zu Lübeck, Institut of Electrical Engineering in Medicine), Jan Graßhoff (Fraunhofer IMTE), Tim Hardel (Clinic for Intensive Care Medicine, Universitätsklinikum Hamburg-Eppendorf), Philipp Rostalski (Universität zu Lübeck, Institut of Electrical Engineering in Medicine, Fraunhofer IMTE)

Abstract

This article proposes a one-compartment COPD model and demonstrates the identification of the model parameters using one illustrative patient data set. A linear lung mechanics model is extended by a volume-dependent airway resistance to mimic the dynamic behavior during expiration in typical COPD patients. The model parameters are analytically identified with a focus on the switching time constants of the lung mechanics. The fitted model parameters are in a pathophysiological plausible range. The results show the ability of this simple model to represent the overall lung mechanics characteristic of COPD disease and a feasible first approach for the identification of the model parameters.

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