Advances in RAB Research
Vol 1 No 1 (2018): Advances in Regulatory Autoantibody Research
https://doi.org/10.18416/RAB.2018.1809020

Research Article

Immunoadsorption in Vascular Dementia
A novel approach to Alzheimer´s Disease?

Main Article Content

Hans Jörgen Grabe 

Abstract

The pathomechanisms leading to Alzheimer´s Disease (AD) are not well understood. Despite several robust hypotheses the nature of the disease seems to be more complex than initially thought. The role of vascular components of AD have been underestimated so far. In this novel treatment approach we perform immunoadsorption over 5 days to remove agonistic autoantibodies (AAB) against α1A-adrenoceptor from the plasma of AD patients. These AAB are thought to alter the functional properties of small blood vessels leading to malfunctions in the supply and clearance processes of the brain.
We will present the first 5 patients with AD who underwent immunoabsorption and who completed a 12-months follow up. Clinical, cognitive and MRI data as well as peripheral endothelial function data and data on AAB clearance will be presented.


The study is funded by Fresenius Medical Care.

Article Details

How to Cite

Grabe, H. J. (2018). Immunoadsorption in Vascular Dementia. Advances in RAB Research, 1(1), Advances in RAB Research, Vol 1, No 1, 2018 -. https://doi.org/10.18416/RAB.2018.1809020