GPCRs are involved in a variety of physiological and pathophysiological processes. So far, much effort has been made on anti-GPCR drug discovery with a focus on the development of small molecules and monoclonal antibodies for the treatment of cancer, infection, metabolic disorders or inflammatory diseases. Recently, functional autoantibodies directed against GPCRs were identified in various diseases associated with pathogenesis, uncovering a potential new field of therapeutic intervention. Thus, the aim of this journal is to combine the current knowledge on the role of GPCRs in different pathologies, their mode of action and state-of-the-art research techniques to identify common fundamental pathways that can be transferred to other disease entities with similar manifestations.

Vol 1 No 1 (2018)

Published: 2018-09-28

The mosaic of autoimmunity: Why we develop autoimmune diseases

The microbiome and metabolism

Yehuda Shoenfeld

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809001 • DOI: 10.18416/RAB.2018.1809001

Network-based analysis reveals signatures of IgG autoantibodies targeting G protein-coupled receptors in health and disease

Otavio Cabral-Marques, Alexandre Marques, Lasse Melvær Giilb, Roberta de Vito, Barbara Elizabeth Engelhardt, Jalid Sehouli, Harald Heidecke, Gabriela Riemekasten

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809002 • DOI: 10.18416/RAB.2018.1809002

To smell the SLE-CNS involvement

Yehuda Shoenfeld

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809003 • DOI: 10.18416/RAB.2018.1809003

Lessons From Anti-TSH-Receptor Autoantibodies: Challenges And Pitfalls In Diagnostics

Paul J. Banga, Simon D. Lytton

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809004 • DOI: 10.18416/RAB.2018.1809004

β1-adrenergic receptor autoantibody levels are higher in patients with Graves’ hyperthyroidism than in matched healthy controls and decrease after anti-thyroid treatment

Anna Lundgren, Karin Tammelin, Mats Holmberg, Helena Filipsson Nyström

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809005 • DOI: 10.18416/RAB.2018.1809005

Patterns of 31 new autoantibodies against G-protein-coupled receptors and growth factors

A. Carvalho-Marques, H. Bittern, C. Fouodo, I. König, S. Schinke, O. Cabral-Marques, H. Heidecke, G. Riemekasten

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809006 • DOI: 10.18416/RAB.2018.1809006

Novel targets in the diagnosis of autoimmune and non-autoimmune diseases

Harald Heidecke

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809008 • DOI: 10.18416/RAB.2018.1809008

Anti-AT1R ab and as cause or contributor to skin fibrosis and interstitial lung disease

Xinhua Yu

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809009 • DOI: 10.18416/RAB.2018.1809009

Signaling and GPCR biology using cell models

Philippe Aurélie

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809012 • DOI: 10.18416/RAB.2018.1809012

Role of antibodies against PAR-1 and PAR-2 in cancer in the kidney transplant recipients

R. Catar, R. Carroll, L. Chen, Q. Li, I. Schramm, M. Simon, O. Wischnewski, A. Kusch, A. Philippe, D. Dragun

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809014 • DOI: 10.18416/RAB.2018.1809014

Sialylated autoantigen-reactive IgG antibodies attenuate disease development in mouse models of lupus nephritis and rheumatoid arthritis

Johann Rahmöller, Yannic C. Bartsch, Alexei Leliavski, Gina-Maria Lilienthal, Janina Petry, Marc Ehlers

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809015 • DOI: 10.18416/RAB.2018.1809015

Autoantibodies targeting complement receptors 3a and 5a are decreased in ANCA-associated vasculitis

Sebastian Klapa, Andreas Koch, Anja Kerstein, Christian Karsten, Harald Heidecke, Markus Huber-Lang, Peter Lamprecht, Gabriela Riemekasten, Antje Müller

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809016 • DOI: 10.18416/RAB.2018.1809016

Impact of regulatory (auto-)antibodies against G-protein-coupled receptors on blood pressure in women ten years after early-onset preeclampsia

Anna Birukov, Hella Muijsers, Harald Heidecke, Nadine Haase, Kristin Kräker, Dominik N. Müller, Florian Herse, Angela Maas, Ralf Dechend

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809017 • DOI: 10.18416/RAB.2018.1809017

Anti-GPCR antibodies in atherosclerosis

Zouhair Aherrahrou, Laurence Johanson, Jeanette Erdmann, Gabriela Riemekasten

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809019 • DOI: 10.18416/RAB.2018.18090019

Immunoadsorption in Vascular Dementia

A novel approach to Alzheimer´s Disease?

Hans Jörgen Grabe

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809020 • DOI: 10.18416/RAB.2018.1809020

First results of the prospective ETiCS-study: acute (microbial-associated) inflammation rather than (infarction-associated) myocardial ischemia triggers the development of cardiac GPCR autoantibodies

Valérie Boivin-Jahns, Chistina Zechmeister, Claudia Schuetz, Niklas Beyersdorf, Stefan Stoerk, Roland Jahns

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809021 • DOI: 10.18416/RAB.2018.1809021

The aptamer BC 007 completely neutralizes agonistic autoantibodies directed against β1-adrenoceptors

Results of a phase 1 trial

Niels-Peter Becker, Johannes Mueller, Annekathrin Haberland, Katrin Wenzel, Gerd Wallukat, Peter Goettel, Sarah Schulze- Rothe, Ingolf Schimke, Georg Golor, Matthias Grossmann, Angela Sinn, Martina Steiper, Tuba Yilmaz, Anne Wallukat, Hanna Davideit, Susanne Becker

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809023 • DOI: 10.18416/RAB.2018.1809023

Agonistic antibody diseases = Autoimmune diseases?

From bench to bedside

Rudolf Kunze

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809024 • DOI: 10.18416/RAB.2018.1809024

Autoantibodies in serum of systemic scleroderma patients: peptide-based epitope mapping indicates increased binding to cytoplasmic domains of CXCR3

Andreas Recke, Ann-Katrin Regensburger, Florian Weigold, Antje Müller, Gabriele Marschner, Harald Heidecke, Gabriele Marschner, Christoph M Hammers, Ralf J. Ludwig, Gabriela Riemekasten

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809025 • DOI: 10.18416/RAB.2018.1809025

Detection and functional characterization of angiotensin receptor Type 1 autoantibodies: establishment and clinical translation

Valérie Boivin-Jahns, Chistina Zechmeister, Claudia Schuetz, Martin J. Lohse, Roland Jahns, Xinhua Yu, Frank Petersen, Stefanie Hahner, Martin Fassnacht

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809026 • DOI: 10.18416/RAB.2018.1809026

Autoantibodies targeting G-protein-coupled receptors in RA and SLE

Xiaoyang Xiaoyang, Qiaoniang Huang, Fengyuan Deng, Juan Chen, Harald Heidecke, Gabriela Riemekasten, Frank Petersen, Xinhua Yu

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809027 • DOI: 10.18416/RAB.2018.1809027

Organotropism of anti-CXCR3/4- and anti-ETAR/-AT1R-mediated leukocyte migration in inflammatory and autoimmune disease

Laurence Johanson, Antje Müller, Zouhair Aherrahrou, Jennifer Hundt, Anja Kerstein, Gabriele Marschner, Silke Pitann, Sara Comdühr, Gesche Weppner, Harald Heidecke, Peter Lamprecht, Christiane Herden, Gabriela Riekemasten

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809029 • DOI: 10.18416/RAB.2018.1809029

New insights into the diagnostics of autoantibodies against G-protein coupled receptors

Pitfalls in the autoantibody detection

Annekathrin Haberland, Johannes Müller, Gerd Wallukat, Katrin Wenzel

Advances in RAB Research, Vol 1, No 1, 2018 • Article ID: 1809033 • DOI: 10.18416/RAB.2018.1809033

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Key Words for submission:

  • Physiological and pathophysiological processes,
  • Anti-GPCR drug discovery,
  • Development of small molecules and monoclonal antibodies,
  • Treatment of cancer, infection, metabolic disorders or inflammatory diseases,
  • Functional autoantibodies against GPCRs,
  • New fields of therapeutic intervention.

Link to symposium: www.rab-symposium.org