Modelling the Hepatic Glucose Production in Type 1 Diabetes during Aerobic Exercise

Bianca Romanski; Steffen Leonhardt; Marian Walter

Proceedings on Automation in Medical Engineering
Vol. 2 No. 1 (2023): Proc AUTOMED

Modelling and control, ID 750

Modelling the Hepatic Glucose Production in Type 1 Diabetes during Aerobic Exercise

Bianca Romanski (Medical Information Technology, RWTH Aachen University), Steffen Leonhardt (Medical Information Technology, RWTH Aachen University), Marian Walter (Medical Information Technology, RWTH Aachen University)

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Mathematical models of the glucose-insulin metabolism are a powerful tool to improve blood glucose control in type 1 diabetes. A high model accuracy is essential. This work investigates whether the hepatic glucose production submodel and the glucagon subsystem of the Lunze model, which was developed for the resting state, remain valid during aerobic exercise. Clinical data of 5 dogs is used for the evaluation. Results suggest, that both the hepatic glucose production submodel and the glucagon subsystem are able to describe the major part of observed changes during aerobic exercise.

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