Transactions on Additive Manufacturing Meets Medicine
Vol 4 No 1 (2022): Trans. AMMM
https://doi.org/10.18416/AMMM.2022.2209666

Scaffolds, Implants and Drug Delivery Systems, ID 666

Digital light processing and drug stability of Dexamethasone-loaded implant prototypes for medical treatment of the inner ear

Main Article Content

Robert Mau (University of Rostock), Philipp Schick (Department of Biopharmacy and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Center of Drug Absorption and Transport, Greifswald, Germany), Farnaz Matin-Mann (Clinic for Oto-Rhino-Laryngology, Hannover Medical School, Hannover, Germany), Ziwen Gao (Clinic for Oto-Rhino-Laryngology, Hannover Medical School, Hannover, Germany), Dorian Alcacer Labrador (HörSys GmbH,Hannover, Germany), Samuel John (HörSys GmbH,Hannover, Germany), Felix Repp (OtoJig GmbH, Hannover, Germany), Thomas Lenarz (Clinic for Oto-Rhino-Laryngology, Hannover Medical School, Hannover, Germany), Werner Weitschies (Department of Biopharmacy and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Center of Drug Absorption and Transport, Greifswald, Germany), Verena Scheper (Clinic for Oto-Rhino-Laryngology, Hannover Medical School, Hannover, Germany), Anne Seidlitz (Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Düsseldorf, Germany), Hermann Seitz (Microfluidics, University of Rostock, Germany)

Abstract

Abstract: 3D printed, patient-individualized drug-eluting implants for the round window niche (RWN) are an innovative, minimally invasive concept for the medical treatment of inner ear disorders. In this study, we investigate the 3D printing via digital light processing (DLP) and the long-term drug stability of Dexamethasone(DEX)-loaded implant prototypes (storage of 12 months at 25 °C/60 % relative humidity and 40 °C/75 % relative humidity (“accelerated”). A PEGDA-based, DEX-loaded (1 % w/v) photopolymer composition was used. We are able to 3D print 3 x 2.5 x2 mm implant prototypes without the need for a supporting structure. The drug was in accordance with the theoretical drug load as detected via HPLC in fresh 3D printed implant prototypes, so there was no significant drug degradation of DEX during the 3D printing process (duration of time ~ 11 mins). Under the long-term storage conditions approx. 15 % of DEX degradation were detected during 12 months (recovery of DEX ~ 90 % after three months and ~ 85 % after 12 months with 25 °C/60 % relative humidity). Drug degradation increased with “accelerated” storage conditions (recovery of DEX ~ 20 % after 12 months). Where there was a post-curing process (t = 30 mins) via UV light curing oven, it led to a pronounced degradation of DEX (recovery of DEX ~ 80 % recently after manufacturing of implant prototypes with post-curing).

Article Details

How to Cite

Mau, R., Schick, P., Matin-Mann, F., Gao, Z., Alcacer Labrador, D., John, S., Repp, F., Lenarz, T., Weitschies, W., Scheper, V., Seidlitz, A., & Seitz, H. (2022). Digital light processing and drug stability of Dexamethasone-loaded implant prototypes for medical treatment of the inner ear. Transactions on Additive Manufacturing Meets Medicine, 4(1), 666. https://doi.org/10.18416/AMMM.2022.2209666

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