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Poly(methyl methacrylate) (PMMA) and polyvinylpyrrolidone (PVP) based polymers were tested for stereolithographic manufacture of tailored drug release systems. We adjusted the drug release by addition of the photopolymers pentaerythritoltriacrylate (PETA) and poly(ethylene glycol) diacrylate (PEGDA). As model drug high molecular bovine serum albumin labeled with fluorescein (BSA-FITC) was used. Changes in swelling behavior and drug release were observed. Higher concentrations of the crosslinker reduced the release and the swelling of PVP. PEGDA had a retarding effect on PVP only, whereas PETA affected both polymers. The stereolithographic designed drug depots could be applied in wound healings and dentistry.