Transactions on Additive Manufacturing Meets Medicine
Vol 1 No 1 (2019): Trans. AMMM
https://doi.org/10.18416/AMMM.2019.1909S03P16

Scaffolds, Implants and Drug Delivery Systems

PMMA and PVP based polymers for stereolitho-graphic manufacture of tailored drug release

Main Article Content

Katharina Wulf (Institute for Biomedical Engineering, Rostock University Medical Center, Rostock, Germany), Celine Riess (Institute for Biomedical Engineering, Rostock University Medical Center, Rostock, Germany), Natalia Dominika Rekowska (Institute for Biomedical Engineering, Rostock University Medical Center, Rostock, Germany), Thomas Eickner (Institute for Biomedical Engineering, Rostock University Medical Center, Rostock, Germany), Hermann Seitz (Chair of Microfluidics, University of Rostock, Rostock, Germany), Niels Grabow (Institute for Biomedical Engineering, Rostock University Medical Center, Rostock, Germany), Michael Teske (Institute for Biomedical Engineering, Rostock University Medical Center, Rostock, Germany)

Abstract

Poly(methyl methacrylate) (PMMA) and polyvinylpyrrolidone (PVP) based polymers were tested for stereolithographic manufacture of tailored drug release systems. We adjusted the drug release by addition of the photopolymers pentaerythritoltriacrylate (PETA) and poly(ethylene glycol) diacrylate (PEGDA). As model drug high molecular bovine serum albumin labeled with fluorescein (BSA-FITC) was used. Changes in swelling behavior and drug release were observed. Higher concentrations of the crosslinker reduced the release and the swelling of PVP. PEGDA had a retarding effect on PVP only, whereas PETA affected both polymers. The stereolithographic designed drug depots could be applied in wound healings and dentistry.

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