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The increasing importance of endovascular surgery requires the development of authentic simulation environments to test new endovascular devices and navigation systems. Purpose of this project was the development of a simulator that mimics endovascular procedures as realistic as possible to minimize the use of animal models. Using the technique of rapid prototyping we developed an endovascular simulator with exchangeable 3D-printed real vascular pathologies. The technique of 3D-printing opened the door to produce endovascular simulators with authentic vascular pathologies. This can reduce the use of animals for research purposes.