Transactions on Additive Manufacturing Meets Medicine
Vol 1 No 1 (2019): Trans. AMMM
https://doi.org/10.18416/AMMM.2019.1909S07T04

Scaffolds, Implants and Drug Delivery Systems

Development of an electrospinning jet control technique for manufacturing vascular grafts

Main Article Content

Christian Grasl (Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria and Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria), Michael Desch (Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria), Martin Helmut Stoiber (Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria and Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria), Michael Röhrich (Department of Anesthesia, Intensive Care Medicine and Pain Therapy, Medical University of Vienna, Austria), Francesco Moscato (Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria), Heinrich Schima (Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria and Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria and Department of Cardiac Surgery, Medical University of Vienna, Austria)

Abstract

Electrospinning is an advanced and versatile additive manufacturing method for the fabrication of small-diameter, nanofibrous scaffolds. However, because of various instabilities, electrospinning leads to unpredictable fiber deposition. Aligned and oriented nanofibers are required to mimic the mechanical anisotropy of soft tissue. With an adapted electrospinning setup the jet was focused or deflected between two auxiliary electrodes and thereby aligned. Tubular grafts with different fiber orientations were manufactured and evaluated in ultimate tensile tests. Fiber orientation affected the maximum tensile force and the compliance in the physiologic blood pressure range.

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