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This paper investigates the use of polymer-ceramic composite scaffolds for bone regeneration. Different ratios between Poly-e-caprolactone (PCL) and Hydroxyapatite (HA) were considered. Scaffolds were produced using two different lay-down patterns (0/90° and 0/45°) and pore sizes (350μm, 500μm and 700μm). Compressive tests and cell proliferation tests are reported. Human adipose derived stem cells (hADSCs) were used for the biological characterization.