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Type 1 diabetes is an autoimmune disease that destroys insulin producing β-cells in the pancreas. Intrahepatic islet transplantation can prolong insulin independence. However, intravascular infusion, suboptimal microenvironment in transplanted site, and significant loss of mass remain elusive. In this study, PEOT-PBT and poly(ester urethane) microwell scaffolds were developed to provide a basis for additive manufacturing of extrahepatic islet transplantation to improve the survival and function of the islets.