Transactions on Additive Manufacturing Meets Medicine
Vol 1 No 1 (2019): Trans. AMMM
https://doi.org/10.18416/AMMM.2019.1909S07T02

Scaffolds, Implants and Drug Delivery Systems

PEOT-PBT and poly(ester urethane) microwell scaffolds for extrahepatic islet transplantation

Main Article Content

Elahe Hadavi (Department of Design, production and management, The university of Twente, Enschede, The Netherlands and Fraunhofer project center at university of Twente, Enschede, The Netherlands), Ian Gibson (Department of Design, production and management, The university of Twente, Enschede, The Netherlands and Fraunhofer project center at university of Twente, Enschede, The Netherlands)

Abstract

Type 1 diabetes is an autoimmune disease that destroys insulin producing β-cells in the pancreas. Intrahepatic islet transplantation can prolong insulin independence. However, intravascular infusion, suboptimal microenvironment in transplanted site, and significant loss of mass remain elusive. In this study, PEOT-PBT and poly(ester urethane) microwell scaffolds were developed to provide a basis for additive manufacturing of extrahepatic islet transplantation to improve the survival and function of the islets.

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